My mom turned 45 this year, and she started experiencing severe joints pain. It's because of the decreasing oestrogen level. Many females experience joints pain when they reach around age of 45, due to reduction in levels of oestrogen. I ordered this for my mom, and she takes a tablet every night with a glass of milk. If you take it regularly, you'll feel the change. Great for females at the brink of menopause and osteoporosis.